HCID 21912066, compound → HCID 21912095, compound

HRID 2307980Notes

Reaction equation

HRID 2307980 reaction equation
[CH2:1]([CH:3]([O:6][C:7]1[C:12]([C:13]([NH2:15])=O)=[C:11]([NH:16][C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=2[CH3:25])[N:10]=[C:9]([CH3:26])[CH:8]=1)[CH2:4][CH3:5])[CH3:2].ClC(Cl)(OC(=O)OC(Cl)(Cl)Cl)Cl.C(N(CC)CC)C>C1COCC1>[CH2:1]([CH:3]([O:6][C:7]1[C:12]([C:13]#[N:15])=[C:11]([NH:16][C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=2[CH3:25])[N:10]=[C:9]([CH3:26])[CH:8]=1)[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 21912066HCID 21912066, compoundHCID 86584328HCID 86584328, compound

Product 1

HCID 21912095HCID 21912095, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by reacting 4-(1-ethyl-propoxy)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinamide with triphosgen/triethylamine in THF. mp 105-107° C., 1H NMR(CDCl3) d 6.90(s,2H), 6.26(brs,1H), 6.05(s,1H), 4.24(m,1 H), 2.28(s,3H), 2.25(s,3H), 2.17(s,6H), 1.72(m,4H), 0.97(t,6H) ppm.

Sources & evidence

ORD record
ord-5e8d4c6071474bb382bac54cb12446f9
Source dataset
uspto-grants-2004_12
Patent number
US06833378B2

Reaction notes

Loading…