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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2308013Generated: October 31, 2026

2,4,6-Trimethyl-3-hydroxypyridine → 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-pyridin-3-yloxy)-nicotinonitrile

https://huagongshe.com/reaction/2308013

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4,6-Trimethyl-3-hydroxypyridineHCID 147625—
Reactant2-Chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinonitrileHCID 86584334—
SolventN-methyl-2-pyrrolidoneHCID 13387—
Product4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-pyridin-3-yloxy)-nicotinonitrileHCID 69901417—

Reaction Steps

The title compound was prepared by heating 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinonitrile with 2,4,6-trimethyl-3-hydroxy-pyridine in NMP.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06833378B2
Source datasetuspto-grants-2004_12
ORD IDord-c05552169558480f8a5663e4f702f6fe
Source noteuspto-grants-2004_12