2,4,6-Trimethyl-3-hydroxypyridine → 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-pyridin-3-yloxy)-nicotinonitrile

HRID 2308013Notes

Reaction equation

HRID 2308013 reaction equation
Cl[C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([NH:11][CH:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[C:3]=1[C:4]#[N:5].[CH3:17][C:18]1[C:23]([OH:24])=[C:22]([CH3:25])[CH:21]=[C:20]([CH3:26])[N:19]=1>CN1C(=O)CCC1>[CH2:13]([CH:12]([NH:11][C:6]1[C:3]([C:4]#[N:5])=[C:2]([O:24][C:23]2[C:18]([CH3:17])=[N:19][C:20]([CH3:26])=[CH:21][C:22]=2[CH3:25])[N:9]=[C:8]([CH3:10])[CH:7]=1)[CH2:15][CH3:16])[CH3:14]

Participants

4

Reactant 2

HCID 1476252,4,6-Trimethyl-3-hydroxypyridineHCID 865843342-Chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinonitrile

Product 1

HCID 699014174-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-pyridin-3-yloxy)-nicotinonitrile

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound was prepared by heating 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinonitrile with 2,4,6-trimethyl-3-hydroxy-pyridine in NMP.

Sources & evidence

ORD record
ord-c05552169558480f8a5663e4f702f6fe
Source dataset
uspto-grants-2004_12
Patent number
US06833378B2

Reaction notes

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