HCID 20745894, compound → HCID 22603515, compound

Temperature

-25 °C

6.5 g (19.8 mmol) 5-[(6-chlorohexyl)oxy]isophthalic acid dimethyl ester were dissolved in 65 ml tetrahydrofuran in an atmosphere of argon. The colourless solution was cooled to −25° C. and then 42 ml (41.6 mmol) of a 1 molar solution of lithiumaluminiumhydrid in tetrahydrofuran were added dropwise over a period of 30 minutes. The reaction mixture was carefully quenched in sequence first with 5 ml of methanol and then with 50 ml of a 1 molar solution of HCl in water. The suspension was stirred for 1 hour at room temperature and subsequently filtered through speedex. The solid residue was washed carefully with 100 ml of tert.-butyl-methylether. The organic phase of the filtrate was separated, washed with 100 ml of a saturated sodium bicarbonate solution and 100 ml of water, dried over magnesium sulfate, filtered and concentrated in vacuum. Column chromatography of the crude product on 250 g of silica gel using dichloromethane:methanol (9:1) as eluent gave 5 g (93%) of [3-[(6-chlorohexyl)oxy]-5-[hydroxymethyl]phenyl]methanol as a white solid.

1. customThe reaction mixture was carefully quenched in sequence first with 5 ml of methanol
2. filtrationsubsequently filtered through speedex
3. washThe solid residue was washed carefully with 100 ml of tert.-butyl-methylether
4. customThe organic phase of the filtrate was separated
5. washwashed with 100 ml of a saturated sodium bicarbonate solution and 100 ml of water
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuum

ORD record

ord-2ac622f69fa444859339f433e720560c

Source dataset

uspto-grants-2004_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06833421B1