HRID230816

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID82029

4-Methylmorpholine 4-oxide

C5H11NO2

结构：CCC(CC)(c1ccc(OCC(O)C(C)(C)C)c(C)c1)c1ccc(C(=O)NCCS(C)(=O)=O)c(C)c1

HCID57763439

未命名化合物

PRODUCTS

生成物

HCID10369260

未命名化合物

收率 76%

AUXILIARIES

试剂、催化剂与溶剂

结构：CCC[N+](CCC)(CCC)CCC.O=[Ru](=O)(=O)[O-]

催化剂HCID178419074

未命名化合物

PROCEDURE

实验过程

Using a procedure analogous to Example 13C, from 4-{1-ethyl-1-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]propyl}-N-(2-methanesulfonylethyl)-2-methylbenzamide, Example 14, (0.08 g, 0.16 mmol), NMO (27 mg, 0.24 mmol), and TPAP (2.8 mg, 0.08 mmol) are reacted for 1 h to give the title compound (0.06 g, 76%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cb29838849f441ad82187c71a8f73a1c
来源数据集: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07566803B2
来源说明: uspto-grants-2009_07

反应 SMILES

[CH2:1]([C:3]([C:21]1[CH:35]=[CH:34][C:24]([C:25]([NH:27][CH2:28][CH2:29][S:30]([CH3:33])(=[O:32])=[O:31])=[O:26])=[C:23]([CH3:36])[CH:22]=1)([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH:14]([OH:19])[C:15]([CH3:18])([CH3:17])[CH3:16])=[C:8]([CH3:20])[CH:7]=1)[CH2:4][CH3:5])[CH3:2].C[N+]1([O-])CCOCC1>CCC[N+](CCC)(CCC)CCC.[O-][Ru](=O)(=O)=O>[CH3:18][C:15]([CH3:16])([CH3:17])[C:14](=[O:19])[CH2:13][O:12][C:9]1[CH:10]=[CH:11][C:6]([C:3]([C:21]2[CH:35]=[CH:34][C:24]([C:25]([NH:27][CH2:28][CH2:29][S:30]([CH3:33])(=[O:32])=[O:31])=[O:26])=[C:23]([CH3:36])[CH:22]=2)([CH2:1][CH3:2])[CH2:4][CH3:5])=[CH:7][C:8]=1[CH3:20]