HCID 12134605, compound → HCID 12134602, compound

HRID 2308191Notes

Reaction equation

HRID 2308191 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[CH2:9][O:8][C:7]2[CH:10]=[C:11]([N+:17]([O-])=O)[C:12]([C:14]([OH:16])=[O:15])=[CH:13][C:6]=2[O:5]1>CO.[Pd]>[NH2:17][C:11]1[C:12]([C:14]([OH:16])=[O:15])=[CH:13][C:6]2[O:5][CH:4]([CH2:3][O:2][CH3:1])[CH2:9][O:8][C:7]=2[CH:10]=1

Participants

4

Reactant 1

HCID 12134605HCID 12134605, compound

Product 1

HCID 12134602HCID 12134602, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

The titled compound of Example 4 (1.22 g, 4.53 mmol) was dissolved in 10 ml of methanol, and added 10% (w/v) Pd/C as a catalyst, followed by stirring for 24 hours at 25° C. Then, the reaction mixture was filtered to give a filtrate, which was then dried under vacuum to obtain a solid compound. The solid compound was recrystallized with ethanol to prepare the titled compound (0.702 g, 65%, m.p. 161-167° C.).

Workup

  1. filtrationThen, the reaction mixture was filtered
  2. customto give a filtrate, which
  3. customwas then dried under vacuum
  4. customto obtain a solid compound
  5. customThe solid compound was recrystallized with ethanol
  6. customto prepare the titled compound (0.702 g, 65%, m.p. 161-167° C.)

Sources & evidence

ORD record
ord-cf4fd74620284c82addd178a87ecf950
Source dataset
uspto-grants-2004_12
Patent number
US06835735B2

Reaction notes

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