反应详情

The titled compound of Example 7, 4-chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline (40 mg, 0.15 mmol) was dissolved in diisopropanol (2.5 ml), where was then added 3-fluoroaniline (33 mg, 0.3 mol) and concentrated hydrochloric acid of catalytic amount, followed by refluxing for 24 hours. Then, the reaction mixture was cooled down to a room temperature to obtain a solid, which was then filtered, washed with diisopropanol and dried under vacuum to prepare the titled compound (24 mg, 47%, m.p. 257-260° C.; mass (m/z;rel) 340.10).

1. temperatureby refluxing for 24 hours
2. customto obtain a solid, which
3. filtrationwas then filtered
4. washwashed with diisopropanol
5. customdried under vacuum
6. customto prepare the titled compound (24 mg, 47%, m.p. 257-260° C.; mass (m/z;rel) 340.10)