3-Chloroaniline → (3-Chlorophenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amine

HRID 2308194Notes

Reaction equation

HRID 2308194 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23]>>[Cl:19][C:20]1[CH:21]=[C:22]([NH:23][C:2]2[C:11]3[C:6](=[CH:7][C:8]4[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=4[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 79323-ChloroanilineHCID 111614544-Chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline

Product 1

HCID 20747425(3-Chlorophenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amineYield 63%

Procedure

The titled compound (25 mg, 63%, m.p. 277-282° C.) was prepared in a similar manner as in Example 8, except for employing 4-chloro-7-methoxymethyl-[1,4]dioxano[2,3-g]quinazoline (30 mg, 0.113 mmol) and 3-chloroaniline (28 mg, 0.226 mmol).

Sources & evidence

ORD record
ord-0881f22e7df74197bb34932533015162
Source dataset
uspto-grants-2004_12
Patent number
US06835735B2

Reaction notes

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