Benzenamine, 3,5-bis(trifluoromethyl)- → [3,5-Bis(trifluoromethyl) phenyl]-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amine

HRID 2308198Notes

Reaction equation

HRID 2308198 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:19][C:20]([F:33])([F:32])[C:21]1[CH:22]=[C:23]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[NH2:24]>>[F:19][C:20]([F:32])([F:33])[C:21]1[CH:22]=[C:23]([NH:24][C:2]2[C:11]3[C:6](=[CH:7][C:8]4[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=4[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:25]=[C:26]([C:28]([F:29])([F:31])[F:30])[CH:27]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 111614544-Chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline

Product 1

HCID 20747424[3,5-Bis(trifluoromethyl) phenyl]-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amineYield 50%

Procedure

The titled compound (8 mg, 50%) was prepared in a similar manner as in Example 8, except for employing 4-chloro-7-methoxymethyl-[1,4]dioxano[2,3-g]quinazoline (10 mg, 0.037 mmol) and 3,5-bis(trifluoromethyl)aniline (17 mg, 0.075 mmol).

Sources & evidence

ORD record
ord-cb01d5815dce45d5b8978b883cb3474f
Source dataset
uspto-grants-2004_12
Patent number
US06835735B2

Reaction notes

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