3,5-Dimethylaniline → (3,5-Dimethylphenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amine

HRID 2308199Notes

Reaction equation

HRID 2308199 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([CH3:27])[CH:26]=1)[NH2:23]>>[CH3:19][C:20]1[CH:21]=[C:22]([NH:23][C:2]2[C:11]3[C:6](=[CH:7][C:8]4[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=4[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:24]=[C:25]([CH3:27])[CH:26]=1

Participants

3

Reactant 2

HCID 79493,5-DimethylanilineHCID 111614544-Chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline

Product 1

HCID 9903075(3,5-Dimethylphenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amineYield 29%

Procedure

The titled compound (10 mg, 29%, m.p. 268-270° C.) was prepared in a similar manner as in Example 8, except for employing 4-chloro-7-methoxymethyl-[1,4]dioxano[2,3-g]quinazoline (26 mg, 0.1 mmol) and 3,5-dimethylaniline (24 mg, 0.2 mmol).

Sources & evidence

ORD record
ord-c7ba345953d6445fb53de57599af5e95
Source dataset
uspto-grants-2004_12
Patent number
US06835735B2

Reaction notes

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