4-Bromo-2-chlorophenol → 4-Bromo-2-chloroanisole

HRID 2308244Notes

Reaction equation

HRID 2308244 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([Cl:9])[CH:3]=1.[N+]([C:13]1C=CC(OC)=CC=1C(F)(F)F)([O-])=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:13])=[C:4]([Cl:9])[CH:3]=1

Participants

3

Reactant 2

HCID 198594-Bromo-2-chlorophenolHCID 5485175-Methoxy-2-nitrobenzotrifluoride

Product 1

HCID 30165374-Bromo-2-chloroanisoleYield 93%

Procedure

Starting from 4-bromo-2-chlorophenol (22 g, 110 mmol) in place of 4-nitro-3-trifluoromethylphenol, the title compound (22 g, 93%, m.p. 69-71° C.) was synthesized in essentially the same manner as described above for 4-nitro-3-trifluoromethylanisole in Step 1, Scheme 1.

Sources & evidence

ORD record
ord-2b12c03f1179406982bde15ca5b5ca76
Source dataset
uspto-grants-2004_12
Patent number
US06835745B2

Reaction notes

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