4-Bromo-2-chloroanisole → 3-Chloro-4-methoxybenzeneboronic acid

HRID 2308245Notes

Reaction equation

HRID 2308245 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([Cl:10])[CH:3]=1.COC1C=CC([B:19]([OH:21])[OH:20])=C(C(F)(F)F)C=1>>[Cl:10][C:4]1[CH:3]=[C:2]([B:19]([OH:21])[OH:20])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

Participants

3

Reactant 2

HCID 30165374-Bromo-2-chloroanisoleHCID 121094604-Methoxy-2-(trifluoromethyl)phenylboronic acid

Product 1

HCID 32475223-Chloro-4-methoxybenzeneboronic acidYield 62%

Procedure

Starting from 4-bromo-2-chloroanisole (5.0 g, 23 mmol) in place of 4-bromo-3-trifluoromethylanisole, the title compound (2.6 g, 62%) was synthesized in essentially the same manner as described above for 4-methoxy-2-trifluoromethylphenylboronic acid in Step 2, Scheme 1.

Sources & evidence

ORD record
ord-0f37c613bc7b4a798c30b2dc681f9d34
Source dataset
uspto-grants-2004_12
Patent number
US06835745B2

Reaction notes

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