Methanol → HCID 22601494, compound

HRID 2308282Notes

Reaction equation

HRID 2308282 reaction equation
[CH2:1]([NH:8][S:9]([C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15](O)=[O:16])(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B.C1COCC1.CO>C1COCC1>[CH2:1]([NH:8][S:9]([C:12]1[CH:20]=[CH:19][CH:18]=[C:14]([CH2:15][OH:16])[CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 6849053-Benzylsulfamoyl-benzoic acidHCID 2723981Borane;tetrahydrofuran

Product 1

HCID 22601494HCID 22601494, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To solution of 3-Benzylsulfamoyl-benzoic acid (395 mg, 1.36 mmol) in THF (10 ml) was added BH3.THF (1M, 5.4 ml, 5.4 mmol) dropwise. After addition, the reaction mixture was allowed to stir for 3 d at room temperature. Methanol was added to the reaction, and the mixture concentrated in vacuo (5×). This compound was used in the next step without further purification.

Workup

  1. additionAfter addition
  2. concentrationthe mixture concentrated in vacuo (5×)
  3. customThis compound was used in the next step without further purification

Sources & evidence

ORD record
ord-06ac59838a1e456e9ed61e70dde6b104
Source dataset
uspto-grants-2004_12
Patent number
US06835731B2

Reaction notes

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