反应详情

Sodium hydroxide (9.8 g) was dissolved in water (61 ml) and ethanol (30 ml) was added. The resultant solution was added to Intermediate 11, and the mixture was heated under reflux for 60 min with stirring under nitrogen. Concentrated hydrochloric acid was added, giving a white precipitate. After stirring for 16 h, the precipitate was filtered off, washed with water and dried in vacuo to give the title compound as a white solid (8.15 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 60 min
3. customgiving a white precipitate
4. stirringAfter stirring for 16 h
5. filtrationthe precipitate was filtered off
6. washwashed with water
7. customdried in vacuo