HRID2308383

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70297

Benzenecarboperoxoic acid, 3-chloro-

C7H5ClO3

HCID10380537

3-Dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone

C11H8Cl2FNO2S

HCID11323779

未命名化合物

PRODUCTS

生成物

HCID70297

Benzenecarboperoxoic acid, 3-chloro-

C7H5ClO3

HCID10380537

3-Dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone

C11H8Cl2FNO2S

HCID10445208

3-chloromethylthio-7-fluoro-1-methyl-4-quinolone

C11H9ClFNOS

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

PROCEDURE

实验过程

In another embodiment, the present invention contemplates a method for the synthesis so of 3-dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone (dichloroflosequinan) comprising: a) providing, i) 3-dichloromethylthio-7-fluoro-1-methyl-4-quinolone, ii) dichloromethane (DCM), and iii) m-chloroperbenzoic acid (MCPBA); and b) reacting, i) 3-chloromethylthio-7-fluoro-1-methyl-4-quinolone, ii) dichloromethane (DCM), and iii) m-chloroperbenzoic acid (“MCPBA”) under conditions such that 3-dichloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone is produced.

WORKUP

后处理

customa) providing

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-140201a26f894c01ab5126a1cf97b9c4
来源数据集: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06835836B2
来源说明: uspto-grants-2004_12

反应 SMILES

[Cl:1][CH:2]([Cl:18])[S:3]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1)=[O:4].ClC(Cl)SC1C(=O)C2C(=CC(F)=CC=2)N(C)C=1.[Cl:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([O:45][OH:46])=[O:44])[CH:38]=1>ClCCl>[Cl:1][CH2:2][S:3][C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1.[Cl:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([O:45][OH:46])=[O:44])[CH:38]=1.[Cl:18][CH:2]([Cl:1])[S:3]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1)=[O:4]