2,3-Dihydro-1-benzofuran-4-amine → 7-Chloro-4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methyl-3-quinolinecarboxamide hydrochloride

HRID 230842Notes

Reaction equation

HRID 230842 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:13])[C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([NH2:16])=[O:15].[O:17]1[C:21]2=[CH:22][CH:23]=[CH:24][C:25]([NH2:26])=[C:20]2[CH2:19][CH2:18]1.Cl.IC1C=C2C(=CC=1)N=CC(C(N)=O)=C2NC1C=CC=C(OC)C=1>C(#N)C>[ClH:1].[Cl:12][C:8]1[C:7]([CH3:13])=[C:6]2[C:11]([C:2]([NH:26][C:25]3[C:20]4[CH2:19][CH2:18][O:17][C:21]=4[CH:22]=[CH:23][CH:24]=3)=[C:3]([C:14]([NH2:16])=[O:15])[CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 117010432,3-Dihydro-1-benzofuran-4-amineHCID 577632334,7-Dichloro-8-methyl-3-quinolinecarboxamideHCID 674246056-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

Product 1

HCID 674232657-Chloro-4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methyl-3-quinolinecarboxamide hydrochloride

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Intermediate 104 was prepared from Intermediate 68 using 2,3-dihydro-1-benzofuran-4-amine in a similar manner to Intermediate 14, using acetonitrile as solvent.

Sources & evidence

ORD record
ord-054dd750686f420ba632b01699a15dca
Source dataset
uspto-grants-2009_07
Patent number
US07566786B2

Reaction notes

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