HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dihydro-1-benzofuran-4-amine → 7-Chloro-4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methyl-3-quinolinecarboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dihydro-1-benzofuran-4-amine | HCID 11701043 | — |
| Reactant | 4,7-Dichloro-8-methyl-3-quinolinecarboxamide | HCID 57763233 | — |
| Reactant | 6-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride | HCID 67424605 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 7-Chloro-4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methyl-3-quinolinecarboxamide hydrochloride | HCID 67423265 | — |
Reaction Steps
Intermediate 104 was prepared from Intermediate 68 using 2,3-dihydro-1-benzofuran-4-amine in a similar manner to Intermediate 14, using acetonitrile as solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07566786B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-054dd750686f420ba632b01699a15dca |
| Source note | uspto-grants-2009_07 |