Sodium Bicarbonate → HCID 86584934, compound

HRID 2308497Notes

Reaction equation

HRID 2308497 reaction equation
[CH3:1][O:2][C:3](=[O:41])[NH:4][C:5]1[S:6][C:7]2[C:13]([C:14]3[N:15]=[C:16]([NH:19]C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[S:17][CH:18]=3)=[CH:12][CH:11]=[C:10]([O:39][CH3:40])[C:8]=2[N:9]=1.C([O-])(O)=O.[Na+]>Cl.CO>[CH3:1][O:2][C:3](=[O:41])[NH:4][C:5]1[S:6][C:7]2[C:13]([C:14]3[N:15]=[C:16]([NH2:19])[S:17][CH:18]=3)=[CH:12][CH:11]=[C:10]([O:39][CH3:40])[C:8]=2[N:9]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 86584935HCID 86584935, compound

Product 1

HCID 86584934HCID 86584934, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

0.070 g of {4-methoxy-7-[2-(trityl-amino)-thiazol-4-yl]-benzothiazol-2-yl}-carbamic acid methyl ester (0.00012 Mol) were heated to reflux in 2 ml of 2.5 M HCl/MeOH for 4 hrs. After cooling to room temperature the pH was adjusted to 7 upon drop wise addition of sat. NaHCO3. A precipitate formed, which was filtered off, washed with ethyl acetate and dried. The title compound was obtained as a white solid (23%), F.p.: 293-296° C. (dec.).

Workup

  1. customA precipitate formed
  2. filtrationwhich was filtered off
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-8373b7e676df47ee93732ac873c20b57
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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