Pyridine → HCID 86584943, compound

HRID 2308513Notes

Reaction equation

HRID 2308513 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13]([C:15]3[S:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[O:14])[S:11][C:7]=2[C:6]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:5][CH:4]=1.[C:27](Cl)(=[O:29])[CH3:28].N1C=CC=CC=1>CN(C=O)C>[C:27]([N:24]1[CH2:23][CH2:22][N:21]([C:6]2[C:7]3[S:11][C:10]([NH:12][C:13]([C:15]4[S:16][C:17]([CH3:20])=[CH:18][CH:19]=4)=[O:14])=[N:9][C:8]=3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:26][CH2:25]1)(=[O:29])[CH3:28]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 865849425-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-piperazin-1-yl-benzothiazol-2-yl)-amide

Product 1

HCID 86584943HCID 86584943, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-piperazin-1-yl-benzothiazol-2-yl)-amide (100 mg, 0.26 mmol) were suspended in DMF (2 ml) and treated with acetyl chloride (22 μl, 0.30 mmol) and pyridine (27 μl, 0.34 mmol) and the mixture stirred for 5 h at ambient temperature. Workup and purification as described in the general procedure C afforded the product as a white solid (55%), MS: m/e=431 (M+H+).

Workup

  1. customWorkup and purification

Sources & evidence

ORD record
ord-e2dfc0f55cea4535b862e3f23f3d220c
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

Loading…