4-Bromo-2-nitroanisole → HCID 86584952, compound

HRID 2308533Notes

Reaction equation

HRID 2308533 reaction equation
BrC1C=CC(OC)=C([N+]([O-])=O)C=1.C[Sn](C)(C)[C:15]1[CH:19]=[CH:18][S:17][CH:16]=1.[CH3:22][O:23][C:24]1[C:29]2[N:30]=[C:31]([NH:33][C:34]([N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)=[O:35])[S:32][C:28]=2[C:27](C2C=CC=CC=2)=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[C:29]2[N:30]=[C:31]([NH:33][C:34]([N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)=[O:35])[S:32][C:28]=2[C:27]([C:15]2[CH:19]=[CH:18][S:17][CH:16]=2)=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 1185334-Bromo-2-nitroanisoleHCID 10014834HCID 10014834, compoundHCID 10155956HCID 10155956, compound

Product 1

HCID 86584952HCID 86584952, compound

Procedure

The title compound was prepared strarting from 4-bromo-1-methoxy-2-nitro-benzene and trimethyl-thiophen-3-yl-stannane as described for morpholine-4-carboxylic acid (4-methoxy-7-phenyl-benzothiazol-2-yl)-amide (Example 157) and obtained as a light yellow solid in about 10% overall yield, MS: m/e=376 (M+H+).

Workup

  1. customobtained as a light yellow solid in about 10% overall yield, MS

Sources & evidence

ORD record
ord-95549267b5864cbdb5557fe459b412b8
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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