Sodium Methoxide → (5-Methoxy-biphenyl-3-yl)-thiourea

HRID 2308556Notes

Reaction equation

HRID 2308556 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)=[S:11])(=O)C1C=CC=CC=1.C[O-].[Na+]>CO>[CH3:20][O:19][C:17]1[CH:18]=[C:13]([NH:12][C:10]([NH2:9])=[S:11])[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 222833191-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea

Product 1

HCID 22283392(5-Methoxy-biphenyl-3-yl)-thioureaYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea (183 mg, 0.51 mmol) in methanol (5 ml) are treated with sodium methoxide (5.4M in methanol, 0.14 ml) and the formed precipitate is filtered off. Washing with methanol yields the product (115 mg, 88%) as off-white powder. MS: m/e=258 (M+).

Workup

  1. filtrationthe formed precipitate is filtered off
  2. washWashing with methanol

Sources & evidence

ORD record
ord-1da8584fab624b88867a2bcf25ae0559
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Reaction notes

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