Hydrochloric Acid → HCID 13826768, compound

Participants

Reaction Steps

Dissolved in 20 ml of ethanol was 4.1 g of 6-(4-chlorobenzoylamino)-8-[4-(2-hydroxyethyl)-1-piperazinyl]-1,7-naphthyridine, followed by a gradual addition of HCl-saturated ethanol while stirring the reaction system under ice-cooling. Thereafter, 200 ml of ether was added further and the resultant crystals were collected by filtration. The crystals were thoroughly washed with ether and then dried, thereby obtaining 4.2 g of the hydrochloride (Compound No. 29) as light yellowish crystals.

Provenance & Evidence