Hydrochloric Acid → HCID 13826768, compound

HRID 2308601Notes

Reaction equation

HRID 2308601 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[CH:10]=[C:11]3[C:16](=[C:17]([N:19]4[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]4)[N:18]=2)[N:15]=[CH:14][CH:13]=[CH:12]3)=[O:7])=[CH:4][CH:3]=1.Cl.CCOCC>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[CH:10]=[C:11]3[C:16](=[C:17]([N:19]4[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]4)[N:18]=2)[N:15]=[CH:14][CH:13]=[CH:12]3)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13826767HCID 13826767, compound

Product 1

HCID 13826768HCID 13826768, compoundYield 188.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolved in 20 ml of ethanol was 4.1 g of 6-(4-chlorobenzoylamino)-8-[4-(2-hydroxyethyl)-1-piperazinyl]-1,7-naphthyridine, followed by a gradual addition of HCl-saturated ethanol while stirring the reaction system under ice-cooling. Thereafter, 200 ml of ether was added further and the resultant crystals were collected by filtration. The crystals were thoroughly washed with ether and then dried, thereby obtaining 4.2 g of the hydrochloride (Compound No. 29) as light yellowish crystals.

Workup

  1. temperaturecooling
  2. filtrationthe resultant crystals were collected by filtration
  3. washThe crystals were thoroughly washed with ether
  4. customdried

Sources & evidence

ORD record
ord-efa0d4c797ae4913ae8a089118a5a786
Source dataset
uspto-grants-1987_09
Patent number
US04690924

Reaction notes

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