Piperazine → HCID 12817082, compound

HRID 2308676Notes

Reaction equation

HRID 2308676 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:16]2[CH2:21][CH2:20][S:19](=[O:22])[CH2:18][CH2:17]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=2[N:7]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[OH:15][CH2:14][CH2:13][NH:12][C:8]1[C:6]2[N:7]=[C:2]([N:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[N:3]=[C:4]([N:16]3[CH2:21][CH2:20][S:19](=[O:22])[CH2:18][CH2:17]3)[C:5]=2[N:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 12817028HCID 12817028, compound

Product 1

HCID 12817082HCID 12817082, compound

Procedure

This compound was prepared analogous to Example 118 from 2-chloro-8-(2-hydroxyethyl-amino)-4-(1-oxido-thiomorpholino)-pyrimido-[5,4-d]-pyrimidine (m.p.: 227°-229° C.) and piperazine.

Sources & evidence

ORD record
ord-fdc6a8881e4342f396dfe29bd0a5de58
Source dataset
uspto-grants-1987_09
Patent number
US04690923

Reaction notes

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