Potassium Carbonate → HCID 136142467, compound

HRID 2308697Notes

Reaction equation

HRID 2308697 reaction equation
Cl.[CH:2]1([N:8]([CH2:29][C:30]([O:32][CH3:33])=[O:31])[C:9](=[O:28])[CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[C:19]2[NH:24][C:25](=[O:27])[CH2:26][N:18]2[CH2:17]3)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH:2]1([N:8]([CH2:29][C:30]([O:32][CH3:33])=[O:31])[C:9](=[O:28])[CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[C:19]2[NH:24][C:25](=[O:27])[CH2:26][N:18]2[CH2:17]3)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 136393704HCID 136393704, compound

Product 1

HCID 136142467HCID 136142467, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of methyl 2-(N-cyclohexyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramidyl)acetate HCl suspended in 50 ml of ether is stirred with one equivalent of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield methyl 2-(N-cyclohexyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramidyl)acetate as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-05d3cdfdccee47b488665136dd647078
Source dataset
uspto-grants-1987_09
Patent number
US04690925

Reaction notes

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