Imidazole → HCID 22055139, compound

HRID 2308707Notes

Reaction equation

[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.C1(=O)[O:11][CH:9]([CH3:10])[CH2:8]O1>>[OH:11][CH:9]([CH3:10])[CH2:8][C:2]1[NH:1][CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 795Imidazole

HCID 7924Propylene Carbonate

Product 1

HCID 22055139HCID 22055139, compound

Conditions

Temperature: 140 °C

Procedure

Mix 6.8 g imidazole and 15.3 g propylene carbonate and heat at 140° C. for 1 hour. Chromatograph the resultant residue on silica gel, eluting with methylene chloride:ethyl acetate (1:1), then with 5→10% methanol in methylene chloride to obtain the title compound of step A.

Workup

washChromatograph the resultant residue on silica gel, eluting with methylene chloride:ethyl acetate (1:1)

Sources & evidence

ORD record: ord-f9a34c300e804b8f938fb7a0efa9ea75
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04690922

Reaction notes

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