Sodium Carbonate → HCID 20187493, compound

HRID 2308756Notes

Reaction equation

HRID 2308756 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].Br[CH:8]([CH3:21])[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)=[O:10].[CH3:22][C:23]1[CH:35]=[CH:34][C:26]([CH2:27][CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:25][CH:24]=1>C(O)C>[CH3:22][C:23]1[CH:24]=[CH:25][C:26]([CH2:27][CH:28]2[CH2:33][CH2:32][N:31]([CH:8]([CH3:21])[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=3)=[O:10])[CH2:30][CH2:29]2)=[CH:34][CH:35]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 2264852-bromo-3-4-dimethoxypropiophenoneHCID 33756034-[(4-Methylphenyl)methyl]piperidine

Product 1

HCID 20187493HCID 20187493, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.4 g (0.05 mol) of sodium carbonate are added to a mixture of 13.65 g (0.05 mol) of 2-bromo-3',4'-dimethoxypropiophenone and 9.46 g (0.05 mol) of 4-(4-methylbenzyl)-piperidine in 50 ml of ethanol and the mixture is heated under reflux for 3 hours. It is then evaporated to dryness and the residue is passed through a column of silica using acetone as the eluant. This gives an oil, which is used as such.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. customIt is then evaporated to dryness
  4. customThis gives an oil, which

Sources & evidence

ORD record
ord-96a13481ddf1492cb0f4ea7207a0d47f
Source dataset
uspto-grants-1987_09
Patent number
US04690931

Reaction notes

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