1-Piperazinecarboxylic acid, ethyl ester → HCID 13957256, compound

HRID 2308945Notes

Reaction equation

HRID 2308945 reaction equation
[N:1]1[C:10]2[C:9](=[O:11])[CH:8]=[CH:7][C:6](=[O:12])[C:5]=2[N:4]=[CH:3][CH:2]=1.[CH2:13]([O:15][C:16]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)=[O:17])[CH3:14]>O1CCOCC1>[CH2:13]([O:15][C:16]([N:18]1[CH2:19][CH2:20][N:21]([C:8]2[C:9](=[O:11])[C:10]3[N:1]=[CH:2][CH:3]=[N:4][C:5]=3[C:6](=[O:12])[CH:7]=2)[CH2:22][CH2:23]1)=[O:17])[CH3:14]

Participants

4

Reactant 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 113556455,8-Quinoxalinedione

Product 1

HCID 13957256HCID 13957256, compoundYield 47.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 160 mg of 5,8-quinoxalinedione and 316 mg of 1-piperazinecarboxylic acid ethyl ester in 10 ml of dioxane was stirred for 3 hours. The resulting solid was collected, washed with ether and dried, giving 150 mg of the desired product as a red solid, mp 180°-195° C. (dec.).

Workup

  1. customThe resulting solid was collected
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-3de90c4c43e24e7282bc5b9440e6243c
Source dataset
uspto-grants-1987_09
Patent number
US04692449

Reaction notes

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