Ethyl Acetate → Acetamide, N-(2-amino-2-methylpropyl)-

HRID 2308967Notes

Reaction equation

HRID 2308967 reaction equation
C([O:4][CH2:5][CH3:6])(=O)C.[NH2:7][CH2:8][C:9]([NH2:12])([CH3:11])[CH3:10]>>[CH3:10][C:9]([NH2:12])([CH3:11])[CH2:8][NH:7][C:5](=[O:4])[CH3:6]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 131282-Methylpropylenediamine

Product 1

HCID 9793774Acetamide, N-(2-amino-2-methylpropyl)-Yield 57.4%

Conditions

Temperature
100 °C

Procedure

A mixture of 26.4 g (0.3 mol) of ethyl acetate and 79.2 g (0.9 mole) of 1,2-diamino-2-methylpropane was heated at 100° C. in a pressured bomb for 36 hours. The reaction mixture was evaporated in vacuo and distilled to give 22.4 g (57.4%) of product which had a boiling point of 100° C. at 0.1 mmHg. This product was identified by NMR and IR spectroscopy.

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. distillationdistilled

Sources & evidence

ORD record
ord-04328bdc50ed4fa3b1fba9d97a500a5c
Source dataset
uspto-grants-1987_09
Patent number
US04692446

Reaction notes

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