HCID 20186855, compound → HCID 172035639, compound

Participants

Reaction Steps

6-{3-[4-(4-Chlorobenzyl)-1-piperazinyl]propoxy}-3-(4-methoxybenzyl)-9-oxo-9H-benzopyrano[2,3-d]-1,2,3-triazole (100 mg) was stirred at 40° C. in trifluoroacetic acid (2 ml) for 1.5 hours and the resulting solution was evaporated to dryness in vacuo. Water was added to the residue followed by dilute aqueous sodium bicarbonate to pH 7. The supernatant was decanted and the residual yellow gum washed by decantation with water. After drying the product was boiled with ethyl acetate to give 20 mg (25%) of title compound of mp 215°-216° C., identical spectroscopically with that prepared in EP No. 34,004.

Provenance & Evidence