HCID 20186855, compound → HCID 172035639, compound

HRID 2309117Notes

Reaction equation

HRID 2309117 reaction equation
[Cl:1][C:2]1[CH:41]=[CH:40][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][O:16][C:17]3[CH:39]=[CH:38][C:20]4[C:21](=[O:37])[C:22]5[N:26]=[N:25][N:24](CC6C=CC(OC)=CC=6)[C:23]=5[O:36][C:19]=4[CH:18]=3)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:41]=[CH:40][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][O:16][C:17]3[CH:39]=[CH:38][C:20]4[C:21](=[O:37])[C:22]5[NH:26][N:25]=[N:24][C:23]=5[O:36][C:19]=4[CH:18]=3)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 20186855HCID 20186855, compound

Product 1

HCID 172035639HCID 172035639, compoundYield 25.3%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

6-{3-[4-(4-Chlorobenzyl)-1-piperazinyl]propoxy}-3-(4-methoxybenzyl)-9-oxo-9H-benzopyrano[2,3-d]-1,2,3-triazole (100 mg) was stirred at 40° C. in trifluoroacetic acid (2 ml) for 1.5 hours and the resulting solution was evaporated to dryness in vacuo. Water was added to the residue followed by dilute aqueous sodium bicarbonate to pH 7. The supernatant was decanted and the residual yellow gum washed by decantation with water. After drying the product was boiled with ethyl acetate to give 20 mg (25%) of title compound of mp 215°-216° C., identical spectroscopically with that prepared in EP No. 34,004.

Workup

  1. customthe resulting solution was evaporated to dryness in vacuo
  2. additionWater was added to the residue
  3. customThe supernatant was decanted
  4. washthe residual yellow gum washed by decantation with water
  5. customAfter drying the product

Sources & evidence

ORD record
ord-e07d66c8f7734e4198ca3460edaca4b1
Source dataset
uspto-grants-1987_09
Patent number
US04692526

Reaction notes

Loading…