Methyl Chloride → HCID 178493584, compound

HRID 2309166Notes

Reaction equation

HRID 2309166 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([O:9]C)[CH:6]=[C:5]([O:11][CH3:12])[N:4]=1.CCl>>[NH2:2][C:3]1[N:8]=[C:7]([OH:9])[CH:6]=[C:5]([O:11][CH3:12])[N:4]=1

Participants

3

Reactant 2

HCID 6327Methyl ChlorideHCID 20185700HCID 20185700, compound

Product 1

HCID 178493584HCID 178493584, compound

Procedure

19.2 g of 2-amino-4,6-dimethoxy-pyrimidine hydrochloride are heated at 150° C. for 2 hours, during which methyl chloride is detached to give 2-amino-4-hydroxy-6-methoxy-pyrimidine. 80 ml of 40% sodium hydroxide solution and 100 ml of dioxane are added, and 22 g of difluorochloromethane are passed in at 70°-75° in the course of 3/4 of an hour. The organic phase is separated off and concentrated to about 1/5 of its volume, the residue is poured into water and the solid precipitate is separated off to give 2.4 g of 2-amino-4-difluoromethoxy-6-methoxy-pyrimidine of melting point 106°-107° C.

Sources & evidence

ORD record
ord-3dcc4963f9324df686370cede98d5f25
Source dataset
uspto-grants-1987_09
Patent number
US04693741

Reaction notes

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