HCID 20185873, compound → HCID 20185872, compound

HRID 2309171Notes

Reaction equation

C(O[O:4][P:5]([CH:11]([CH2:17][CH:18]([P:29]([O:35]OCC)([O:31]OCC)=[O:30])[P:19]([O:25]OCC)([O:21]OCC)=[O:20])[C:12]([O:14]CC)=[O:13])([O:7]OCC)=[O:6])C>Cl>[P:5]([CH:11]([CH2:17][CH:18]([P:19]([OH:21])([OH:25])=[O:20])[P:29]([OH:31])([OH:35])=[O:30])[C:12]([OH:14])=[O:13])([OH:6])([OH:7])=[O:4]

Participants

Conditions

Temperature: 100 °C

Procedure

190 g of ethyl 2,4,4-tris(diethoxyphosphono)butyrate are dissolved in 600 ml of concentrated hydrochloric acid and stirred at 100° C. for 16 hours, hydrogen chloride being passed in at the same time. The reaction mixture is then evaporated to dryness, and the residue is dissolved in water and converted into the dipotassium salt using the appropriate amount of KOH. The dipotassium salt was recrystallized from aqueous methanol. 88.5 g (60% of theory) of the product are obtained.

Workup

customThe reaction mixture is then evaporated to dryness
dissolutionthe residue is dissolved in water
customThe dipotassium salt was recrystallized from aqueous methanol
custom88.5 g (60% of theory) of the product are obtained

Sources & evidence

ORD record: ord-e7b161c8aa7e4da7990a5ab784723d07
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04693884

Reaction notes

Loading…