反应详情

温度

5 °C

To a solution of tert-butyl isocyanate (0.991 g) in methylene chloride (8 ml) was added dropwise to a mixture of N-amino-1,2,3,6-tetrahydropyridine hydrochloride (1.346 g) and triethylamine (1.012 g) in methylene chloride (40 ml) under ice bath cooling. The mixture was stirred for an hour at about 5° C. The reaction mixture was evaporated to dryness, and then the residue was dissolved in ethyl acetate (50 ml). The solution was washed with water (40 ml), dried over magnesium sulfate and evaporated to dryness. The crude residue was washed with ether and dried to give N-[(tert-butylcarbamoyl)amino]-1,2,3,6-tetrahydropyridine (0.50 g).

1. temperaturecooling
2. customThe reaction mixture was evaporated to dryness
3. dissolutionthe residue was dissolved in ethyl acetate (50 ml)
4. washThe solution was washed with water (40 ml)
5. dry with materialdried over magnesium sulfate
6. customevaporated to dryness
7. washThe crude residue was washed with ether
8. customdried