Hydrogen Bromide → 106487-34-7

HRID 2309190Notes

Reaction equation

HRID 2309190 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2.[BrH:22]>>[BrH:22].[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 13755078HCID 13755078, compound

Product 1

HCID 3065051106487-34-7

Procedure

1.55 g of the product of Example 2 in 15 ml of 48% hydrobromic acid were refluxed for 2 hours with stirring under an inert atmosphere. After evaporating to dryness under reduced pressure, crystallizing the oil obtained from ethanol, filtering, washing with ether, drying, and purifying by crystallization from methanol, 1.31 g of 1,3-dihydro-7-hydroxy-4-(1-propyl-3-piperidinyl)-2H-indol-2-one hydrobromide melting at 210° C. were obtained.

Workup

  1. customAfter evaporating to dryness under reduced pressure
  2. customcrystallizing the oil
  3. customobtained from ethanol
  4. filtrationfiltering
  5. washwashing with ether
  6. customdrying
  7. custompurifying by crystallization from methanol

Sources & evidence

ORD record
ord-b84a7a7cde554212b05b27bbafb1e347
Source dataset
uspto-grants-1987_09
Patent number
US04694011

Reaction notes

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