4-Methylbenzylamine → HCID 20186082, compound

Participants

Reaction Steps

3-Chloro-4-phthalimido-4,5-dihydroisoxazole (4 g, 16 mmol) was dissolved in 50 ml of dried tetrahydrofuran. 4-Methylbenzylamine (2.18 g, 18 mmol) was added at room temperature and the reaction solution was stirred at room temperature for 4 hours. The reaction mixture was concentrated in vacuo, and the residue recrystallized from chloroform to give 4.8 (80.7%) of the desired product.

Provenance & Evidence