4-Methylbenzylamine → HCID 20186082, compound

HRID 2309197Notes

Reaction equation

HRID 2309197 reaction equation
[Cl:1][C:2]1[CH:6]([N:7]2[C:11](=[O:12])[C:10]3=[CH:13][CH:14]=[CH:15][CH:16]=[C:9]3[C:8]2=[O:17])[CH2:5][O:4][N:3]=1.[CH3:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=1>O1CCCC1>[Cl:1][C:2]1[CH:6]([NH:7][C:11](=[O:12])[C:10]2[C:9](=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([NH:24][CH2:23][C:22]2[CH:25]=[CH:26][C:19]([CH3:18])=[CH:20][CH:21]=2)=[O:17])[CH2:5][O:4][N:3]=1

Participants

4

Reactant 2

HCID 660354-MethylbenzylamineHCID 9837847HCID 9837847, compound

Product 1

HCID 20186082HCID 20186082, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Chloro-4-phthalimido-4,5-dihydroisoxazole (4 g, 16 mmol) was dissolved in 50 ml of dried tetrahydrofuran. 4-Methylbenzylamine (2.18 g, 18 mmol) was added at room temperature and the reaction solution was stirred at room temperature for 4 hours. The reaction mixture was concentrated in vacuo, and the residue recrystallized from chloroform to give 4.8 (80.7%) of the desired product.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue recrystallized from chloroform

Sources & evidence

ORD record
ord-8966b1294d814f8db5ee3f6506681085
Source dataset
uspto-grants-1987_09
Patent number
US04694016

Reaction notes

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