Water → Bacitracin Copper Lysocellin

Participants

Reaction Steps

A solution of 3.0 g of copper lysocellin, prepared as described in Example B above, in 25 ml of methanol was stirred while 2.8 g of bacitracin (reg) was added thereto. The mixture was stirred at room temperature for 1 hour. Water was added slowly to precipitate the complex. The crude complex precipitated as a tacky semi-solid which on continued stirring was recovered as a filterable amorphous solid. The crude product was slurried with ethyl acetate, isolated and dried at 40° C. under 5 millimeters (mm) Hg pressure.

Provenance & Evidence