Water → Bacitracin Manganese Lysocellin

Participants

Reaction Steps

A solution of 6.5 g of manganese lysocellin, prepared as described in Example D above, in 60 ml of methanol was stirred while 7.0 g bacitracin (reg) was added. The solution was stirred at room temperature for four hours. Stirring was continued and water was added slowly to precipitate a tacky semi-solid. The solids were isolated by decantation and washed with fresh water to obtain a filtrable amorphous solid. The solids were isolated, washed with water and dried. The crude product was slurried with toluene (10 ml/g) to obtain an amorphous product.

Provenance & Evidence