4-Chlorobenzoyl chloride → 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid

Participants

Reaction Steps

By using 10 g of D-tryptophane and 9 g of 4-chlorobenzoyl chloride, and a method similar to that described in reference Example 6, recrystallized from methanol-water, there was obtained 12.5 g of 2-(4-chlorobenzoylamino)-3-(indol-3-yl)propionic acid. Colorless needle-like crystals. Melting point: 100°-102° C. [α]D20 +51.5° (C=1, methanol)

Provenance & Evidence