huagongshe.com
HRID2309236

反应详情

EQUATION

反应方程式

HRID 2309236 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)c1ccc(Cl)cc1
HCID8501

4-Chlorobenzoyl chloride

C7H4Cl2O

结构：N[C@H](Cc1c[nH]c2ccccc12)C(=O)O
HCID9060

D-Tryptophan

C11H12N2O2

PRODUCTS

生成物

1
结构：O=C(NC(Cc1c[nH]c2ccccc12)C(=O)O)c1ccc(Cl)cc1
HCID2787526

N-(4-Chlorobenzoyl)tryptophan

C18H15ClN2O3

收率 74.5%

PROCEDURE

实验过程

By using 10 g of D-tryptophane and 9 g of 4-chlorobenzoyl chloride, and a method similar to that described in reference Example 6, recrystallized from methanol-water, there was obtained 12.5 g of 2-(4-chlorobenzoylamino)-3-(indol-3-yl)propionic acid. Colorless needle-like crystals. Melting point: 100°-102° C. [α]D20 +51.5° (C=1, methanol)

WORKUP

后处理

  1. customrecrystallized from methanol-water