反应详情

4-(7-Chloro-4-quinolinylamino)benzenesulphonyl chloride hydrochloride (23.4 g, 0.06 mol) was added portionwise to a well stirred mixture of aqueous sodium carbonate (60 g in 600 ml water) and 2-aminomethyl-1 ethyl pyrrolidine (7.8 g, 0.06 mol) in chloroform (600 ml) at about 10° C. The ice bath used for cooling was removed and, after 11/2 hours, the mixture was filtered. The chloroform layer was separated and dried (MgSO4). Concentration under reduced pressure caused precipitation of a solid, which was collected by filtration and dried. Recrystallisation from ethanol gave the title compound (10.5 g), melting point 200°-201.5° C.

1. temperaturefor cooling
2. customwas removed
3. filtrationafter 11/2 hours, the mixture was filtered
4. customThe chloroform layer was separated
5. dry with materialdried (MgSO4)
6. concentrationConcentration under reduced pressure
7. customprecipitation of a solid, which
8. filtrationwas collected by filtration
9. customdried
10. customRecrystallisation from ethanol