Trifluoroacetic acid → HCID 13603312, compound

HRID 2309382Notes

Reaction equation

HRID 2309382 reaction equation
[CH2:1]([N:3]1[C:11]2[CH:10]=[C:9]3[CH:12](O)[CH2:13][O:14][C:8]3=[CH:7][C:6]=2[CH2:5][C:4]1=[O:16])[CH3:2].FC(F)(F)C(O)=O>C(#N)C>[CH2:1]([N:3]1[C:11]2[CH:10]=[C:9]3[CH:12]=[CH:13][O:14][C:8]3=[CH:7][C:6]=2[CH2:5][C:4]1=[O:16])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 13603320HCID 13603320, compound

Product 1

HCID 13603312HCID 13603312, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

To a slurry of 30.3 g. (0.138 mole) of 5-ethyl-3-hydroxy-6-oxo-2,3,6,7-tetrahydro-furo[2,3-f]indole in 950 ml. of acetonitrile at 25° C. was added 7 ml. of a 10% solution of trifluoroacetic acid in acetonitrile, and the reaction was allowed to stir at room temperature for 12 hours. The clear solution was evaporated to give a quantitative yield of the product. A small sample was recrystallized from hexane, m.p. 112°-113° C.

Workup

  1. customThe clear solution was evaporated

Sources & evidence

ORD record
ord-e0829d7180024207bf7a152d7e41da97
Source dataset
uspto-grants-1987_09
Patent number
US04695571

Reaction notes

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