Ethanol → HCID 21864670, compound

HRID 2309383Notes

Reaction equation

HRID 2309383 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[CH2:11](O)[CH3:12]>[Ni]>[CH2:11]([NH:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1)[CH3:12]

Participants

4

Reactant 2

HCID 702EthanolHCID 38411022,3-Dihydro-1-benzofuran-5-amine

Product 1

HCID 21864670HCID 21864670, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Conditions

Temperature
25 °C

Procedure

A mixture of 148 g. (1.09 moles) of 5-amino-2,3-dihydrobenzofuran and 93 g. of W2 Raney nickel in 850 ml. of ethanol was heated to reflux for 24 hours. The reaction was cooled to 25° C., filtered and evaporated to give a quantitative yield of the desired intermediate.

Workup

  1. additionA mixture of 148 g
  2. temperatureto reflux for 24 hours
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-cd6177102c7a472badc109a935ed793f
Source dataset
uspto-grants-1987_09
Patent number
US04695571

Reaction notes

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