反应详情

A mixture of 17.7 g. (0.1 mole) of 1-ethyl-5-hydroxyoxindole, 8.66 ml. (0.1 mole) of allyl bromide and 13.8 g. (0.1 mole) of potassium carbonate in 500 ml. of acetone was heated at reflux for 3 hours. The reaction was cooled, filtered and concentrated. The residue was purified by chromatographing on 550 g. of silica gel using diethyl ether-hexane (1:1, v:v) as the eluent to give 9.8 g. (45% yield) of the desired compound.

1. additionA mixture of 17.7 g
2. temperatureat reflux for 3 hours
3. temperatureThe reaction was cooled
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by chromatographing on 550 g
7. customto give 9.8 g