反应详情

Stir a mixture of 4-(3-chloro-phenyl)-2-methoxymethyl-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidine in a solution of 30% HBr in HOAc (25 mL) at 60° C. for 3 hours. Evaporate the mixture, adjust the pH to basic with 1M NaOH, and collect a tan solid. Purify by liquid chromatography (3:1 hexanes/EtOAc) to obtain 2-bromomethyl-4-(3-chloro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidine as a yellow solid.

1. customEvaporate the mixture
2. customcollect a tan solid
3. customPurify by liquid chromatography (3:1 hexanes/EtOAc)