反应详情

Stir the solution of 2,3-dichloro-4-(3-chloro-4-fluoro-phenyl)-pyridine (100 mg) in morpholine (2 mL) 3 hours at 80° C., concentrate, partition between H2O and EtOAc, dry over Na2SO4, and concentrate under vacuum. Purify by preparative TLC (3:1 hexanes/EtOAc) to give 4-[6-chloro-4-(3-chloro-4-fluoro-phenyl)-pyridin-2-yl]-morpholine.

1. concentrationconcentrate
2. custompartition between H2O and EtOAc
3. dry with materialdry over Na2SO4
4. concentrationconcentrate under vacuum
5. customPurify by preparative TLC (3:1 hexanes/EtOAc)