HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-[6-Chloro 4-(3-chloro-4-fluoro-phenyl)-pyridin-2-yl]-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2,3-Dichloro-4-(3-chloro-4-fluoro-phenyl)-pyridine | HCID 86610311 | — |
| Product | 4-[6-Chloro 4-(3-chloro-4-fluoro-phenyl)-pyridin-2-yl]-morpholine | HCID 57761141 | — |
Reaction Steps
Stir the solution of 2,3-dichloro-4-(3-chloro-4-fluoro-phenyl)-pyridine (100 mg) in morpholine (2 mL) 3 hours at 80° C., concentrate, partition between H2O and EtOAc, dry over Na2SO4, and concentrate under vacuum. Purify by preparative TLC (3:1 hexanes/EtOAc) to give 4-[6-chloro-4-(3-chloro-4-fluoro-phenyl)-pyridin-2-yl]-morpholine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07566712B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-d7489e9033b24ce3b102dbdd67f5af71 |
| Source note | uspto-grants-2009_07 |