HCID 14253840, compound → HCID 14253842, compound

HRID 2309483Notes

Reaction equation

HRID 2309483 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[O:9][CH2:10][CH2:11][NH:12][C:13]2[C:14]3[C:19]([N:20]=[C:21]4[C:26]=2[C:25](=[O:27])[CH2:24][CH2:23][CH2:22]4)=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:28]2[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=2)[O:9][CH2:10][CH2:11][NH:12][C:13]2[C:14]3[C:19]([N:20]=[C:21]4[C:26]=2[CH:25]([OH:27])[CH2:24][CH2:23][CH2:22]4)=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14253840HCID 14253840, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 14253842HCID 14253842, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a cooled solution of 5.55 g of 3,4-dihydro-9-[[2-[bis(4-fluorophenyl)methoxy]ethyl]amino]acridin-1(2H)-one in 100 ml of tetrahydofuran was added 6.5 ml of 1M solution of lithium aluminum hydride in tetrahydrofuran. This was stirred for 1 hour at ice bath temperature.

Sources & evidence

ORD record
ord-64cebc7ddda1413f9b93aa84504748fc
Source dataset
uspto-grants-1987_09
Patent number
US04695573

Reaction notes

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