1,4-Dioxane hydrochloride → 1-{4-(3-Chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-4-propyl-piperazin-2-one

HRID 230950Notes

Reaction equation

HRID 230950 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([Cl:27])[CH:21]=3)[CH:17]=[C:16]([N:28]3[CH2:33][CH2:32][N:31]([C:34]4[C:39]([C:40]([F:43])([F:42])[F:41])=[CH:38][CH:37]=[CH:36][N:35]=4)[CH2:30][CH2:29]3)[N:15]=2)[C:10](=[O:44])[CH2:9]1)=O)(C)(C)C.Cl.O1CCO[CH2:48][CH2:47]1>>[Cl:27][C:22]1[CH:21]=[C:20]([C:18]2[CH:17]=[C:16]([N:28]3[CH2:33][CH2:32][N:31]([C:34]4[C:39]([C:40]([F:42])([F:43])[F:41])=[CH:38][CH:37]=[CH:36][N:35]=4)[CH2:30][CH2:29]3)[N:15]=[C:14]([N:11]3[CH2:12][CH2:13][N:8]([CH2:6][CH2:47][CH3:48])[CH2:9][C:10]3=[O:44])[N:19]=2)[CH:25]=[CH:24][C:23]=1[F:26]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 577611454-{4-(3-Chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 577616391-{4-(3-Chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-4-propyl-piperazin-2-one

Procedure

Treat 4-{4-(3-chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-3-oxo-piperazine-1-carboxylic acid tert-butyl ester with HCl/dioxane (4M) using the procedure described in Example 1-J step 3 to afford the title piperazine-one.

Sources & evidence

ORD record
ord-da930d1dbcc14bc188adecc37081ac6c
Source dataset
uspto-grants-2009_07
Patent number
US07566712B2

Reaction notes

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